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KMID : 0371919890020010017
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Journal of Wonju College of Medicine
1989 Volume.2 No. 1 p.17 ~ p.24
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Effect of Intracerebroventricular Calcitionin on Experimental Gastric Ulcers in Rats
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Abstract
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Ulceration induced by stress is an important clinical causes of upper gastrointestinal bleeding. The etiology of such ulceration is thoughts to be multifactorial. Calcitonin is a polypeptide hormone of 32 aminoacid residues. Recently, much evidence is accumulating to suggest that calcitonin may inhibit gastric acid secretion and stress ulcer formation by a central action.
The present study investigated, in rats, the influence of intracerebroventricular (ICV) administration of calcitionin on gastric acid secretion, stress and aspirin induced ulceration and the possible mechanism of action.
The results obtained are as follows:
1. ICV administration of calcitonin suppressed basal gastric acid secretion in a dose-dependent manner.
2. Gastric acid secretion stimulated by TRH was markedly suppressed by ICV administration of calcitonin.
3. Stress ulcers induced by cold restraint and TRH administration were diminished by ICV administration of calcitonin.
4. Aspirin induced ulcers were diminished by ICV administration of calcitonin.
From the above results it is concluded that calcitonin supperesses gastric acid secretion. In particular, calcitonin suppresses TRH induced gastric acid secretion and stress ulcer formation. The inhibitroy effect of calcitonin seems to be centrally mediated.
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